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The activation of TGR5 receptors by secondary bile acids inhibits NLRP3 inflammasome activation via the cAMP-PKA pathway, promotes macrophage polarization towards the M2 phenotype and attenuates the inflammatory response 148

Revista Cubana de Investigaciones Biomdicas , 14, 1, 12-1995, p

Takeuchi T, Tanaka Y, Ishiguro N, Yamanaka H, Yoneda T, Ohira T, Okubo N, Genant HK, van der Heijde D (2016) Effect of denosumab on Japanese patients with rheumatoid arthritis: a doseresponse study of AMG 162 (Denosumab) in patients with rheumatoid arthritis on methotrexate to Validate inhibitory effect on bone Erosion (DRIVE)-a 12-month, multicentre, randomised, double-blind, placebo-controlled, phase II clinical trial

A significant minority of patients with BASD in our cohort had pruritus

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